Pharmacy Prior Authorization Criteria

Nereus (tradipitant) - PA, NF

Indications for Prior Authorization

Nereus (tradipitant)

• For diagnosis of Prevention of Vomiting
  Indicated for the prevention of vomiting induced by motion in adults

Criteria

Nereus

Prior Authorization

Length of Approval: 1 Month(s)

• Used for the short-term prevention of vomiting induced by motion
AND
• Patient is 18 years of age or older
AND
• Dosing frequency will be limited to once daily dosing
AND
• Trial and failure, contraindication, or intolerance to two conventional motion sickness therapies including but not limited to the following: environmental modification, transdermal scopolamine and antihistamines (e.g., dimenhydrinate, meclizine) [3] [4]
AND
• Requested drug is not being prescribed for off-label use (e.g., drug induced nausea and vomiting, morning sickness, vertigo)

Nereus

Non Formulary

Length of Approval: 1 Month(s)

• Submission of medical records (e.g., chart notes) confirming product will be used for the short-term prevention of vomiting induced by motion
AND
• Patient is 18 years of age or older
AND
• Submission of medical records (e.g., chart notes) confirming dosing frequency will be limited to once daily dosing
AND
• Submission of medical records (e.g., chart notes) or paid claims confirming trial and failure, contraindication, or intolerance to two conventional motion sickness therapies including but not limited to the following: environmental modification, transdermal scopolamine and antihistamines (e.g., dimenhydrinate, meclizine) [3] [4]
AND
• Submission of medical records (e.g., chart notes) confirming requested drug is not being prescribed for off-label use (e.g., drug induced nausea and vomiting, morning sickness, vertigo)

P & T Revisions

2026-10-07, 2026-06-12

References

1. Nereus Prescribing Information, Drugs at FDA, Vanda Pharmaceuticals Inc. Accessed May 2026.
2. Prevention and Treatment of Motion Sickness, American Academy of Family Physicians, Andrew Brainard, MD, MPH, Chip Gresham, MD, Am Fam Physician. 2014;90(1):41-46, May 2026.
3. UpToDate - Motion Sickness, Adrian J Priesol, MD, FRCPC, May 2026.
4. CDC Yellow Book: Health Information for International Travel, John F. Golding, 2026

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Revision History

• 2026-10-07: Drug-specific non-formulary criteria added to guideline
• 2026-06-12: New Program

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