Glycerol phenylbutyrate (Ravicti®)


Indications for Prior Authorization:

  • Treatment of adult and pediatric patients (> 2 years) patients with urea cycle disorders (UCD)

Patients must meet the following criteria for the indication(s) above:

  • Patients symptoms cannot be managed with dietary protein restrictions and/or amino acid supplementation alone

The Following Conditions Do Not Meet the Criteria for Use as Established by the WHA P & T Committee:

  • All non-FDA approved uses not listed in the approved indications
  • Patient must be on protein restricted diet

Recommended Dosing:

  • Initial dose in treatment naïve patient is 4.5 to 11.2 mL/m2/day in three divided doses with food


One year


Last review date: December 2, 2013

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