Fosnetupitant/palonosetron (Akynzeo®)

SELF ADMINISTRATION - ORAL

OFFICE ADMINISTRATION - IV

Indications for Prior Authorization:
  • Capsules: Indicated in combination with dexamethasone in adults for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of cancer chemotherapy, including, but not limited to, highly emetogenic cancer chemotherapy
  • Injection: Indicated in combination with dexamethasone in adults for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy
    • Limitations of use: Akynzeo for injection has not been studied for the prevention of nausea and vomiting associated with anthracycline plus cyclophosphamide chemotherapy
Dosing:
  • Highly emetogenic chemotherapy, including cisplatin-based chemotherapy:
    • Capsules: 1 capsules 1 hour before chemotherapy
    • Injection: 1 vial of Akynzeo infused over 30 minutes starting 30 minutes before chemotherapy
  • Anthracyclines and cyclophosphamide-based chemotherapy and chemotherapy not considered highly emetogenic
    • Capsules: 1 capsules 1 hour before chemotherapy

 

Last review date: May 28, 2019